منابع مشابه
The interaction of inositol hexaphosphate with methaemoglobin.
1. Inositol hexaphosphate causes the shape of the oxidation-reduction equilibrium curve to become hyberbolic at acid pH values. 2. Inositol hexaphosphate also causes a decrease in the alkaline oxidation Bohr effect at these same pH values. 3. These results support the idea that inositol hexaphosphate causes methaemoglobin to take up the deoxyhaemoglobin quaternary structure at pH6.5.
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In idiopathic methaemoglobinaemia, of which we have investigated'some cases, the occurrence of an atypical form of methaemoglobin' abnormally resistant to reduction has been postulated by Lian, Frumusan & Sassier [1939] as an aetiological factor. It thus became of interest to examine the evidence which has been put forward by Vestling [1942] against the unitary view of methaemoglobin. This auth...
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The time course of methaemoglobin reduction in human erythrocytes treated with nitrite was studied at pH 7.4, 37 degrees C, in the presence or absence of Methylene Blue, and the changes in methaemoglobin, intermediate haemoglobins and oxyhaemoglobin during the reaction were analysed by isoelectric-focusing on Ampholine/polyacrylamide-gel plates. In both cases, with or without the dye, the inter...
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MetHb is often defined as oxidised Hb; that is the haem iron is oxidised from the ferrous (Fe) state to the ferric (Fe) state. In addition, in metHb the sixth coordination site of the haem iron is liganded to a water molecule; this shifts the absorbance maxima from that of Hb causing metHb to be chocolate brown in colour (acid form). At pH ~8 the water molecule is replaced by a bound hydroxyl g...
متن کاملMRI Detects Oxidative Stress Induced by Methaemoglobin
Fluorescence than Ferrous Hb In the absence of haemoglobin (Hb) products, no cisparinaric Acid (PnA) fluorescence is lost. However, upon addition of ferrous Hb, there is an increasing amount of fluorescence lost. Substantial fluorescence quenching is seen on the addition of extracellular mHb, with significantly less using an intracellular product. This suggests that the cellular membrane is an ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1895
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1895.sp000547